Xenotropic and Other Murine Leukemia Virus-Related Viruses in Humans

Xenotropic Murine leukemia virus-related virus (XMRV) in Iranian HIV Patients

Background: Despite of isolation of Xenotropic murine leukaemia virus-related virus (XMRV) from the patients acquired prostate cancer in 2006 and patients with chronic fatigue syndrome in 2009, there have been controversial findings about its potential role in human diseases and frequencies in different population groups. In the present study, we aimed to determine the frequency of XMRV genome ...

Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples

Xenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as endogenous proviruses in mouse genomes. Here, we review the relationship of the human and mouse virus isolates and discuss the potential complic...

Presence of murine leukemia virus (MLV)-related virus gene sequences in a commercial RT-PCR reagent.

BACKGROUND The recent identification of murine leukemia virus (MLV)-related viruses in patients with chronic fatigue syndrome (CFS) has aroused much interest, not least among sufferers. However, other studies failed to detect these viruses in CFS patients. METHODS We wanted to establish a MLV-related virus real-time PCR for routine diagnostics. RESULTS Our study identified false positive ML...

Figure S3. Bayesian maximum clade credibility phylogeny of 22Rv1 cell line derived XMRV clones, patient derived XMRV sequences and other murine leukaemia viruses

Internal organization of endogenous proviral DNAs of xenotropic murine leukemia viruses.

The internal organization of endogenous xenotropic murine leukemia virus proviruses was determined in a series of blot hybridization experiments in which DNA from several different inbred mouse strains, digested with restriction enzymes known to cleave xenotropic proviral DNAs at least twice, was annealed to generalized murine leukemia virus or xenotropic env-specific DNA probes. Comigrating ba...

Helper-independent mink cell focus-inducing strains of Friend murine type-C virus: potential relationship to the origin of replication- defective spleen focus-forming virus

Recent studies have indicated that both the replication-defective spleen focus-forming virus (SFFV) in the Friend virus complex and the helper-independent mink cell focus-inducing (MCF) viruses derived from AKR-murine leukemia virus (MuLV) are env gene recombinants between ecotropic virus and xenotropic virus. In an attempt to isolate additional env gene recombinants between Friend murine leuke...